蛋白类药物缓释微球制剂的研究进展

doi:10.3969/j.issn.1672-3384.2015.03.002

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摘要目的：总结蛋白类药物临床应用中存在的问题，以及现有的解决策略，以加快蛋白类药物的临床应用。方法：通过文献调研，笔者综述了现有微球制剂常用的材料、制备技术及目前存在的问题。结果与结论 ：介绍一种可制备尺寸均一且粒径可控载药微球的新型膜乳化技术，有望提高我国微球制剂的质量，具有广阔的发展应用前景。

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	吕丕平
	王玉霞
	赵荣生
	梁晓东
	和龙
	马光辉

关键词 ：蛋白质药物, 微球制剂, 临床应用, 高分子材料, 膜乳化剂术

Abstract：Objective : To accelerate the clinical application of bioactive proteins and peptides, we summarized the existing problems and current solutions. Methods : The common materials, preparation technology and existing problems of microsphere delivery system were reviewed in this paper. Results and conclusion : We propose a new membrane emulsification technique for preparing uniform-sized and size-controllable microspheres, which is expected to improve the quality of microsphere formulations in China and presents a broad application prospect.

Key words： protein drugs microsphere formulations clinical application research progress membrane emulsification technique

收稿日期: 2014-05-20

R944

通讯作者: 王玉霞，马光辉 E-mail: yxwang@ipe.ac.cn

引用本文:

吕丕平，王玉霞，赵荣生，梁晓东，和龙，马光辉. 蛋白类药物缓释微球制剂的研究进展[J]. 临床药物治疗杂志, 2015, 13(3): 5-9.
LV Pi-ping, WANG Yu-xia, CUI Yi-min, LIANG Xiao-dong, HE Long, MA Guang-hui. Research progress of sustained-release system of proteinic drug. CLINICAL MEDICATION JOURNAL, 2015, 13(3): 5-9.

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