Abstract：Objective: To explore the dosage regimen of multiple antiepileptic therapy for patients with refractory seizure under regular dialysis and to study interpreting plasma concentration values. Methods: The therapeutic process of one case of refractory seizure under regular dialysis was analyzed with applying professional knowledge of therapeutic drug monitoring (TDM) and dialysis pharmacokinetic profile. Results: TDM help interpret clinical effects, improve drug efficacy, and reduce drug side effects Supported by the pharmaceutical professional knowledge, refractory seizure was controlled and the regimen was optimized. Conclusion: For patients receiving multiple-antiepileptic therapy under peritoneal dialysis, an individualized dosage regimen should be made by analyzing dialysis pharmacokinetic and drug interaction according to TDM, besides paying carefully attention to drug side ef fects.
邹羽真, 杜小莉. 血透患者应用多联抗癫痫药物治疗抽搐1例[J]. 临床药物治疗杂志, 2016, 14(6): 78-80.
ZOU Yu-zhen, DU Xiao-li. A case of seizure treated with multiple antiepileptic therapy under dialysis. CLINICAL MEDICATION JOURNAL, 2016, 14(6): 78-80.
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2016, Vol. 14 
