Abstract：Objective: To collect and analyze the data of 96 patients with drug-induced liver injury, and to explore its risk factors. Methods: Retrospective analysis of the clinical data of 96 patients with drug-induced liver injury, the onset of analysis time relationship under different parting liver damage, compared types of drugs cause liver damage and clinical treatment and outcome, at the same time using Logistic regression analysis to screen the susceptible risk factors of the drug-induced liver injury. Results: In this study, 96 cases of drug-induced liver injury with the highest proportion of liver cell damage type (44.79%), 68.75% of patients in the medication liver injury happened in 5 to 90 days. In liver injury caused by the types of drugs, antitumor drugs (32.29%) and traditional Chinese medicine (29.17%) accounted for the largest, involving both medicines were 13 and 14 species. Effect of prognosis of 96 cases were good, the hepatic function indexes returned to normal between 18 and 90 days after drug withdrawal. By Logistic regression analysis, the age higher than 50 or more, sex for women, BMI ≥ 28kg/m2 , allergy and combined hyperlipidemia was listed as one of risk factors (P < 0.05). Conclusion: The drug-induced liver injury is common on clinic, and more for liver cell damage type, need to properly handle in time, lest causing acute liver failure. The clinical medicine will be focus on monitoring in the process of antineoplastic drugs and traditional Chinese medicine (TCM) of rational drug use, avoiding the happening of liver injury. For the elderly and women, higher BMI value, a history of drug allergy and three tenors disease, the doctors should focus on more.
[1] Liver Doctor Editorial Department. The mortality of drug induced liver disease ranked at the fifth in the world[J]. Liver Doctor, 2006, (5): 68-69.
[2] 杨佼, 吕文良. 药物性肝损伤临床研究及治疗进展[J]. 现代中西医结合杂志, 2012, 21(12):1359-1363.
[3] SIERRA F, TORRES D. A concise and structured review of drug-induced toxic hepatic disease [J]. Ann Hepatol, 2004, 3(1):18- 25.
[4] Benichou C. Criteria of drug-induced liver disorders. Report of an international consensus meeting[J]. J Hepatol, 1990, 11(2):272-276.
[5] Danan G, Benichou C. Causality assessment of adverse reactions to drugs-I. A novel method based on the conclusion s of international cosensus meetings: application to drug-induced liver injuries[J]. J Clin Epidemiol, 1993, 46: 1323-1330.
[6] 许建明, 徐张巍, 胡祥鹏. 112 例药物性肝损伤的临床关联性评价[J]. 中华消化杂志, 2005, 25(8):451-453.
[7] 李平, 谢同柄. 132 例药物性肝损伤临床分析[J]. 实用肝脏病杂志, 2010, 1(1):48-50.
[8] 张琪, 彭劼, 侯金林. 药物性肝损害临床特点及预后相关因素分析[J]. 广东医学, 2008, 29(7):1102-1103.
[9] 中华医学会消化病分会肝胆疾病协作组. 全国多中心急性药物性肝损伤住院病例调研分析[J]. 中华消化杂志, 2007, 27(7):439-442.
[10] Ma B, Yeo W, Hui P, et al. Acute toxicity of adjuvantdoxorubicin and cyclophosphamide for early breast cancer: aretrospective review of Chinese pationts and comparison withan historic Western series[J]. Radiother Oncol, 2002, 62(2): 185-189.
[11] 于乐成, 陈成伟. 药物性肝病[J]. 肝脏, 2008, 13(3):238-243.
[12] 秦敏, 白文元, 谭莉莉. 回顾性分析临床药物性肝病109 例[J]. 世界华人消化杂志, 2007, 15(28):3041-3044.
[13] 陆玮婷, 李军. 276 例药物性肝损伤的病因和临床表现分析[J]. 中华肝脏病杂志, 2006, 14(11):832-834.
[14] Andrade R J, Lucena M I, Kaplow it z N, et al. Outcome of acute idiosyncratic drug-induced liver injury :long-term follow-up in a hepatotoxity registry[J]. Hepatology, 2006, 44: 1581-1588.
[15] Molleston J P, Fontana R J, Lopez M J, et al. Characteristics of idiosyncratic drug induced liver injury in children: results from the DILIN prospective study[J]. J Pediatr Gastroenterol Nutr, 2011, 53:182-189.
[16] 许雪飞, 王菲, 刘芬, 等. 药物性肝损伤临床调查及影响因素分析[J]. 中国临床药理学杂志, 2014, 30(3):216-218.
[17] Sgro C, Clinard F, Ouazir K, et al. Incidence of drug-induced hepatic in juries: a French population based study[J]. Hepatology, 2002, 36: 451-455.
[18] Bj?rnsson E, Olsson R. Out come and prognostic markers in severe drug -induced liver disease[J]. Hepatology, 2005, 42: 481-489.
[19] 王明媚，周亮，张鑫，等. 药物性肝损伤的诊断和防治研究进展[J]. 中国药业, 2014, 23(7):94-96.
[20] 梁雁, 刘晓, 张海燕, 等. 325 例药物性肝损伤分析[J]. 中国现代应用药学, 2010, 27(12):1144-1148.
2017, Vol. 15 
