Abstract:Streptococcus pneumoniae is one of the major pathogens of pneumonia, as wel as otitis media, sinusitis, septicemia and meningitis in children. The pneumococcal vaccination is an important measure to prevent pneumococcal disease, providing good protection to vaccinees and creating herd immunity ef ect, reducing the use of antibiotic. This article briefly describes the prevalence, drug resistance to Streptococcus pneumoniae, vaccination and other preventive strategies of pneumococca l disease.