Abstract：Objective: To find drug-drug interactions of clinical value and provide evidence-based suggestions and idea of pharmaceutical care for clinical pharmacists majored in the endocrinology pharmacy through analysis of combinational drug use in outpatients with diabetes mellitus in the endocrinology department of Beijing Shijitan Hospital in 2016. Methods: The prescriptions prescribed by outpatient clinicians in the endocrinology department of our hospital in 2016 were randomly extracted, 1 day a week, evenly distributed from Monday to Sunday, 48 days altogether. The basic information of the patients, classifications of drugs, indications, and frequencies of drug use were arranged, and the combinations of drugs with potential interactions were summarized and analyzed. Results: The top ten antidiabetic agents, combinationally-used drugs, and complications were identified, and nine groups of combinational use of drugs with potential risks were found concerning antidiabetic, antihypertensive, and lipid-lowering drugs. Conclusion: Clinical pharmacists could provide clinical interventions and evidence-based pharmaceutical suggestions on drugs with narrow therapeutic window and drugs which may influence liver enzymes metabolism, influence the effects of other drugs, and enhance adverse drug reactions. This method is hopeful to help clinical pharmacists majored in the endocrinology pharmacy in other hospitals to carry out pharmaceutical care with pertinence and promote rational use of drugs.
甄霞,金锐,顾红燕,孙路路. 基于内分泌门诊糖尿病患者联合用药数据统计的药学监护点分析[J]. 临床药物治疗杂志, 2017, 15(5): 65-69.
ZHEN Xia, JIN Rui, GU Hong-yan, SUN Lu-lu. Analysis of pharmaceutical care based on statistics of drug combinations in outpatients with diabetes mellitus in the endocrinology department. CLINICAL MEDICATION JOURNAL, 2017, 15(5): 65-69.
[1] 《中国糖尿病防控专家共识》专家组, 中国糖尿病防控专家共识[J], 中华预防医学杂志, 2017, 51(1):12.
[2] 纪立农, 陈莉明, 郭晓蕙, 等. 中国慢性疾病防治基层医生诊疗手册（糖尿病分册）2015 年版[J]. 中国糖尿病杂志, 2015, 23(8):673-701.
[3] 中华医学会糖尿病学分会, 中国2 型糖尿病防治指南（2013 年版） [J]. 中华糖尿病杂志, 2014, 6(7):447-498.
[4] Tirkkonen T, Heikkil? P, Vahlberg T, et al, Epidemiology of CYP3A4- mediated clopidogrel drug- drug interactions and their clinical consequences[J]. Cardiovasc Ther, 2013, 31(6):344-351.
[5] 张克, 他汀类药物对氯吡格雷抗血小板作用影响的Meta 分析[D]. 山东: 山东大学, 2013.
[6] 戎智韬, 项荣武, 杨静, 等. 他汀类药物对氯吡格雷抗血小板作用影响的Meta 分析[J]. 沈阳药科大学学报, 2015, (3)：223-233.
[7] 周海峰, 沈杰, 纪芳, 等. Beers 标准联合STOPP/START 准则评价我院内科老年住院患者潜在不适当用药[J]. 中国药房, 2016, 27(23):3212-3214.
[8] Tannenbaum C, Sheehan N L. Understanding and preventing durg-durg and durg-gene interactions[J]. Expert Rev Clin Pharacol, 2014, 7(4): 533-544.
[9] 朱慧婷, 徐召飞, 临床合用那格列奈对氟伐他汀药代动力学的影响[J]. 济宁医学院学报, 2015, 38(5):324-326.
[10] Kim Y, Park K, Kang W. Effect of fluvastatin, lovastatin, nifedipine and verapamil on the systemic exposure of nateglinide in rabbits[J]. Biopharm Drug Dispos, 2010, 31(8-9): 443-449.
[11] Takanohashi T, Koizumi T, Mihara R, et al. Prediction of the metabolic interaction of nateglinide with other drugs based on in vitro studies[J]. Drug Metab Pharmacokinet, 2007, 22(6): 409-418.
[12] Sharma S, Chhetri H P, Alam K. A study of potential drug-drug interactions among hospitalized cardiac patients in a teaching hospital in Western Nepal[J]. Indian J Pharmacol, 2014, 46(2):152- 156.
[13] 谢雅君, 关笑婵, 李晓晔, 等. 与磺脲类药物相关的药物相互作用[J]. 药品评价, 2015, 12(17):18-20.
[14] 鲁姝, 武莹, 于静远, 等，脑梗死患者用药回顾性分析及临床药学服务模式的探讨[J]. 临床药物治疗杂志, 2016, 14(4):72-76.
2017, Vol. 15 
