Abstract：Objective: To explore the features about drug fever, ensure medicine use correctly and avoid serious consequences caused by drug fever. Methods: 20 cases were included from 2011 to 2014. Characteristics of cases were summarized and the laboratory examination results were retrospectively analyzed in the study. Results: The temperature of 20 patients was back to normal. The median time of drug fever was 6 days, and the mean time was 6.9days. The body temperature was higher in the afternoon or at night. The maximal temperature is 37.8 to 40.3℃ . Relatively slow pulse occurred in all cases. Transaminase and blood sedimentation value increased in some cases. Conclusion: Doctors should pay more attention to the drug fever caused by antibiotics in order to decrease the adverse reaction of antibiotics.
[1] 丁雄芳, 胡毅坚. 浅析抗生素致药物热[J]. 药学实践杂志, 2009, 27(1):71-72.
[2] 陈娟, 雷艳青. 药物热20 例浅析[J]. 临床合理用药, 2010, 3(1):65-66.
[3] 苏长海, 王星. 药物热概述[J]. 中国药师, 2011(03).
[4] 李雪梅. 抗生素致药物热47 例分析[J]. 安徽医学, 2011, 32(2):204.
[5] Cunha B A. Clinical approach to fever in the neurosurgical intensive care unit: Focus on drug fever[J]. Surg Neurol Int, 2013,4(Suppl5):S318-322.
[6] Vodovar D, Le Beller C, Megarbane B, et al. Drug fever: a descriptive cohort study from the French national pharmacovigilance database[J]. Drug Saf, 2012, 35(9):759-767.
[7] Niven D J, Leger C, Stelfox H T, et al. Fever in the critically ill: A review of epidemiology, immunology, and management[J]. Intensive Care Med, 2012, 27(5):290-297.
[8] Tan X Y, He Q Y. Chinese literature review of etiology distribution of adult patients with fever of unknown origin from 1979 to 2012[J]. Zhonghua Nei Ke Za Zhi, 2013, 52(12):1013-1017.
[9] Li Z, Shen J, Li Q. Drug Fever Induced by Piperacillin/Tazobactam in a Scoliosis Patient: A Case Report[J]. Medicine (Baltimore). 2015, 94(46):e1875.
[10] Linares T, Fernandez A, Soto MT, et al. Drug fever caused by piperacillin-tazobactam[J]. J Investig Allergol Clin Immunol, 2011, 21(3): 250-251.
[11] 赵妍, 康红军, 王彬, 等. 药物热的诊断思维( 附二例报告)[J]. 临床误诊误治, 2014, 27(01):64-67.
[12] 朱允和, 沈学远, 陈力, 等. 浅谈药物热的发病机制及临床诊疗[J]. 中国医药指南, 2011, 9(18):226-227.
[13] Cunha B A. The diagnostic significance of relative bradycardia in infectious disease [J]. Clin Microbiol Infect, 2000, 6(12): 633-634.
[14] Sharif S, Kong M W, Drakakis J. Fever of unknown origin (FUO) in a renal transplant recipient due to drug fever from sirolimus[J]. Infection, 2016.
[15] Vodovar D, Le Beller C, Lillo-Le-Louet A, et al. Drug-induced fever: a diagnosis to remember[J]. Rev Med Interne, 2014, 35(3):183-188.
[16] 郑新, 路玫. 注射用哌拉西林钠他唑巴坦钠致药物热的临床分析[J]. 中国药房, 2015, 26(18): 2503-2505.
2017, Vol. 15 
