Abstract：Objective:To summarize the adverse reactions of heamocoagulase agkistrodon for injection, so as to probe into the regularity and clinical manifestations of ADR and to provide reference for the rational drug use. Methods:Retrospective analysis the ADR induced by heamocoagulase agkistrodon in intravenous injection occurred in Beijing Obstetrics Gynecology Hospital Affiliated to Capital Medical University from January 2014 to February 2017. And then summarized the literature in database. Results: ADR mainly occurred within 30 min after heamocoagulase agkistrodon injection and affected multiple system of the body, even including severe anaphylactic shock. The results were identical with those reported in literature. Conclusion: Through the analysis, close attention should be paid for assessment before use and for monitoring during heamocoagulase agkistrodon application. Effective rescue measures should be given in time when ADR appears.
张宁,李心蕾,袁偲偲,李轶凡,王爱华. 注射用尖吻蝮蛇血凝酶不良反应报告分析及文献汇总[J]. 临床药物治疗杂志, 2017, 15(7): 40-43.
ZHANG Ning, LI Xin-lei, YUAN Si-si, LI Yi-fan, WANG Ai-hua. Analysis of adverse reactions of heamocoagulase agkistrodon for injection and literature review. CLINICAL MEDICATION JOURNAL, 2017, 15(7): 40-43.
2017, Vol. 15 
