111例非离子型含碘对比剂不良反应文献分析

doi:doi:10.3969/j.issn.1672-3384.2017.06.008

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摘要目的：归纳总结碘海醇、碘普罗胺、碘帕醇、碘佛醇、碘克沙醇等5 种非离子型含碘对比剂所致药品不良反应的临床特点及发生规律，为降低临床用药风险提供参考。方法：对中国期刊全文数据库文献进行检索，对其中涉及以上5 种非离子型含碘对比剂所致不良反应病例报告进行统计分析。结果：5 种非离子型含碘对比剂共检索到111 例不良反应，重度过敏反应最多（50.4%）。大多数反应发生于给药10min 内。111 例不良反应中，36 例(32.4%) 事前曾行碘过敏试验，6 例(5.4%) 曾用过碘对比剂，仍然发生了过敏反应。结论：使用非离子型碘对比剂时，在用药前询问过敏史、用药中和停药后密切观察的意义大于行碘过敏试验。对于既往有使用碘对比剂所致过敏史的患者，建议采用预先给药方案预防复发。

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	裴艺芳
	倪倩
	任佚
	姜文亮
	封宇飞
	胡欣

关键词 ：非离子型含碘对比剂, 不良反应, 过敏反应, 文献分析

Abstract：Objective: To summarize the clinical characteristics and regularity of adverse drug reactions (ADRs) induced by the following 5 kinds of non-ionic iodine contrast agents: iohexol, iopromide, iopamidol, ioversol and iodixanol, and provide references for reducing clinically medication-related risks. Methods: Case reports of ADRs induced by 5 kinds of non-ionic iodine contrast agents mentioned above were collected from China National Knowledge Infrastructure (CNKI), and analyzed statistically. Results: Among all of the ADRs induced by the 5 kinds of non-ionic iodine contrast agents, severe allergic reactions (50.45%) accounted for the majority. Most of the ADRs happened within 10min. Among these 111 ADRs, 36 ones (32.4%) had hypersensitive test in advance, and 6 ones (5.4%) had ever used iodine contrast agents, but allergic reaction happened as well. Conclusion: Before using non-ionic iodine contrast agents, investigating patients’ allergy history in advance as well as observing their response during and after medication process may be more significant than conducting iodine allergy test. For the patients with an allergy history of iodine contrast agents, pretreatment may be a good advice.

Key words： non-ionic iodine contrast agents ADRs allergic reaction literature analysis

收稿日期: 2016-12-09

R969.3

通讯作者: 胡欣 E-mail: peiyf2013pivas@126.com

引用本文:

裴艺芳,倪倩,任佚,姜文亮,封宇飞,胡欣. 111例非离子型含碘对比剂不良反应文献分析[J]. 临床药物治疗杂志, 2017, 15(6): 30-33.
PEI Yi-fang, NI Qian, REN Yi, JIANG Wen-liang, FENG Yu-fei, HU Xin. Adverse drug reactions induced by non-ionic iodine contrast agents: literature analysis of 111 cases. CLINICAL MEDICATION JOURNAL, 2017, 15(6): 30-33.

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