Literature analysis of 64 cases of adverse drug reactions caused by compound liquorice tablets and the enlightenment
SONG Qin1，2, WANG Biao1, LI Jia1, ZHANG Cui-lian1*
1 Department of Joint Surgery, Affiliated of Traditional Chinese Medicine of Xinjiang Medical University, Urumqi 830000, China; 2Department of Anesthesiology , Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi 830000, China
Abstract：Objective:To understand the types and characteristics of the adverse drug reactions caused by compound liquorice tablets and provide the basis for revising the drug instruction and reference for clinical medication. Methods:The Wanfang database and Chinese journal full-text database were retrieved. The literatures of adverse drug reactions (ADRs) caused by compound liquorice tablets were statistically analyzed. Results: There were 64 cases of ADRs related with compound liquorice tablets, including 31 cases of exogenous corticosteroid syndrome, 7 cases of allergic reactions, 20 cases of opioid toxicity and 6 cases of other ADRs. Addicted patients were mainly elderly patients with long-term medication history. Opioid poisoned patients were all younger than 1 year old babies. Conclusion: Compound liquorice tablets is classified as one prescription drug. It is recommended to revise the drug instruction due to a variety of ADRs, and to add the infants and children’s medication information in the section of 'Precautions'. it should be contraindicated in infants. Children and adult dose conversion table should be referred to for calculating the dose for infants when the drug has to be used. The information that elderly patients should not take the drug for a long time need to be added in the drug instruction.
宋钦,王彪,李嘉,张翠莲. 64例复方甘草片的不良反应文献分析与启示[J]. 临床药物治疗杂志, 2017, 15(7): 63-68.
SONG Qin, WANG Biao, LI Jia, ZHANG Cui-lian. Literature analysis of 64 cases of adverse drug reactions caused by compound liquorice tablets and the enlightenment. CLINICAL MEDICATION JOURNAL, 2017, 15(7): 63-68.
2017, Vol. 15 
