Efficacy and adverse effect of lenalidomide in relapsed/refractory chronic lymphocytic leukemia patient: a meta-analysis
LIANG Liang, ZHAO Ming, ZHU Yuan-chao , HU Xin, YANG Li-ping*
Department of Pharmacy, Beijing Hospital National Cewter of Gerontology, Assessment of Clinical Drugs Risk and Individual Application Key
Laboratory, Beijing 100730, China
Abstract:Objective: Efficacy and adverse effect of lenalidomide monotherapy or in combination with anti-CD20 monoclonal antibody (mAbs) in relapsed/refractory chronic lymphocytic leukemia was evaluated. Methods: We conducted a literature search using the PubMed/Medline and Embase database, as well as Chinese language databases, including the Chinese Biomedical Literature Database, and Wanfang. We also searched the Cochrane Library for any recent systematic review on the subject, the ClinicalTrials.gov database, the websites of European Medicines Agency (EMA) and US Food and Drug Administration (FDA). R software and was used for all statistical analyses. Results: 17 cohort studies were included in the final analyses. Pooled estimates of cumulative prevalence of total ORR was 42.10% (95%CI :32.41%-52.43%). The pooled ORR in regimen with lenalidomide plus anti-CD20 antibody and lenalidomide mono-therapy are 60.01% (95% CI , :53.86%-65.86%) and 24.31%(95% CI :16.34%-34.67%) respectively.Cumulative prevalence of neutropenia was 61.98%(95% CI , 54.01%-69.35%). For thrombocytopenia and anemia, cumulative prevalence were 21.33%(95% CI :14.15%-30.84%)and 11.32%(95% CI :8.46%-14.98%) respectively. Moreover, cumulative prevalence of infection rate was33.52% (95% CI :28.99%-38.38%). Other adverse effect included tumor flare, deep vein thrombosis and fatigue. Conclusion: Lenalidomide is a considerable regimen for relapsed/refractory CLL patient.
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