Abstract：Objective :To investigate significance of monitoring of blood concentration of vancomycin for neonates application in neonates. Methods :From January 2012 to November 2014, 174 cases of hospitalized newborns treated by vancomycin were selected. High performance liquid chromatography (HPLC) method was used for the determination of peak plasma concentration and trough concentration of vancomycin in children with the adverse reactions occurrence observed. Results : In 174 cases, the minimum value of trough blood concentration of vancomycin was 2.04 mg?L-1,and the maximum value was 13.49 mg?L-1 with the average of (6.01±2.18) mg?L-1. The minimum value of peak concentration was 9.04 mg?L-1, and the maximum value was 50.47mg?L-1, with average of (32.17±11.08) mg?L-1.There were 101 cases of children with serum trough concentration<5 mg?L-1, the total effective rate 93.07%, and the rate of adverse reaction 16.83%. There were 45 cases of children with serum trough concentration in 5~10 mg?L-1, the total effective rate 100%, and the rate of adverse reaction 16.83%. There were 28 cases of children with serum trough concentration >10 mg?L-1, the total effective rate 100%, and the rate of adverse reaction 28.57%. Efficacy and adverse reactions among three different blood concentration treatments had no significant difference (P >0.05). The main adverse reactions were liver damage and hearing damage, with liver damage occurrence rate 9.20% and the incidence of hearing damage 10.34%. With the increase of vancomycin serum trough concentrations, the occurrence rate of adverse reaction did not have trend to increase (X2=2.032, P =0.154). conclusion : The application of vancomycin in neonates had high rate of incidence of liver damage and hearing damage, and the clinical application should be strictly controlled for doseand indications. Individualized treatment with the blood concentration monitoring should be performed.
2015, Vol. 13 
